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Pharmacogenomics of Contraception: Genetic Variants and Etonogestrel Pharmacokinetics

Sep 16, 2019

Overview

The Pharmacogenomics of Contraception: Genetic Variants and Etonogestrel Pharmacokinetics study aims to research the pharmacology of commonly used contraceptives. The study will look specifically at the progestin etonogestrel and examine the relationship between genetic variants and hormone levels to pave the way for future research.

 

Study Information

The study will enroll 700 women of reproductive age who have had an Etonogestrel (ENG) implant for over a year. They will have blood drawn and answer questions about their history when it comes to contraceptives and gynecological examinations. Researchers will then examine the samples with DNA extraction and a gene study. Participants will also be asked for consent to use the blood samples for future research.

 

Inclusion Criteria

  • Women ages 18-45
  • Have had an ENG contraceptive implant in place for 12-36 months

 

Exclusion Criteria

  • Use of medications or supplements in the past four weeks which could impact serum ENG levels through inhibition or induction of CYP enzymes (specifically CYP-3A4)
  • Medical conditions that could impact baseline liver function (e.g. hepatitis, cirrhosis)
  • Body mass index (BMI) less than 18.5

 

Location

University of Colorado Denver

Aurora, Colorado, United States, 80045

Contact: Lisa Powers       lisa.powers@ucdenver.edu  

Contact: Rebecca Seale       Rebecca.Seale@ucdenver.edu 

Principal Investigator: Aaron Lazorwitz, MD University of Colorado, Denver

 

Sponsors/Collaborators

University of Colorado, Denver

Society of Family Planning

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