Overview
The Effectiveness of Orally Dosed Emergency Contraception in Obese Women study looks at increasing dosage of oral emergency contraceptives in obese women. Obese women have been shown to be significantly more likely to experience failures of emergency contraceptives than women with more normal BMI. The study will focus on emergency contraceptives that contain ulipristal acetate (UPA).
Study Information
The study aims to look at 112 participants and look at the delay in follicular rupture among obese women who take an escalated dose of emergency contraceptives. Women will either be given two doses or one dose of 30mg UPA-based emergency contraceptives and then will receive the opposite dose in their next menstrual cycle. In total, the women will receive 3 doses – the difference is when the doses will be administered.
Inclusion Criteria
- Generally healthy women ages 18-35
- Regular menses (every 21-35 days) experiencing an ovulatory screening cycle with a progesterone level of 3 ng/mL or greater
- Subjects must have a BMI of >30kg/m2 and weight at least 80kg or more OR a BMI <25kg/m2 and a weight of less than 80kg.
Exclusion Criteria
- Metabolic disorders including uncontrolled thyroid dysfunction and Polycystic Ovarian Syndrome
- Impaired liver or renal function
- Actively seeking or involved in a weight loss program (must be weight stable) pregnancy, breastfeeding, or seeking pregnancy
- Recent (within last 8 weeks) use of hormonal contraception
- Current use of drugs that interfere with metabolism of sex steroids
- Smokers
Locations
OHSU
Portland, Oregon, United States, 97239
Principal Investigator: ALISON EDELMAN, MD, MPH Oregon Health and Science University
Sponsors/Collaborators
Oregon Health and Science University
National Institutes of Health (NIH)
Clinical Trials
View All Clinical TrialsHormonal Contraceptive Health Education for Adolescent Males
The Hormonal Contraceptive Health Education for Adolescent Males trial looks at educational electronic applications…
Quick Start of Highly Effective Contraception
The Quick Start of Highly Effective Contraception study looks at the failure rates of contraception in instances of…
UCSF College Health Study on Contraceptive Training and Education at Community Colleges
The UCSF College Health Study on Contraceptive Training and Education at Community Colleges looks to measure…
Contraception Initiation Feasibility in the Pediatric ED
The Contraception Initiation Feasibility in the Pediatric ED study aims to look at initiating hormonal…
Injectable DMAU for Male Contraception in Healthy Male Volunteers
The Injectable DMAU for Male Contraception in Healthy Male Volunteers study looks at the male contraceptive…